N. Sinha

Direct Ink Writing of Graphene Oxide Reinforced 13-93B1 Bioactive Glass Scaffolds for Bone Tissue Engineering Applications

This paper fabricates graphene oxide-reinforced 13-93B1 bioactive glass scaffolds using direct ink writing and evaluates their mechanical, structural, and biological properties for bone tissue engineering.

Regulation and Function of a Polarly Localized Lignin Barrier in the Exodermis

This study identifies a polar lignin cap in tomato exodermis that functions similarly to the endodermal Casparian strip but is regulated by distinct transcription factors.

Deep characterization of cancer drugs mechanism of action by integrating large-scale genetic and drug screens

DeepTarget integrates genetic and drug screens to predict cancer drugs' mechanisms of action, including primary and secondary targets and specificity, with high accuracy.

A suberized exodermis is required for tomato drought tolerance

This study identifies exodermal suberization as critical for drought tolerance in tomato, contrasting with Arabidopsis endodermis, and highlights the role of MYB92 and ASFT in this process.

Prediction of cancer treatment response from histopathology images through imputed transcriptomics

ENLIGHT-DeepPT predicts cancer treatment response from H&E slides by first imputing transcriptomics and then using that data to predict response across multiple therapies and cancer types.

The genomic basis of the plant island syndrome in Darwin's giant daisies

This study characterizes the genomic basis of the plant island syndrome in Darwin's giant daisies by analyzing the genome of Scalesia atractyloides, identifying subgenomes, polyploidization events, and genes under selection.

Protein reservoirs of seeds are composites of amyloid and amyloid-like structures facilitating sustained release during germination and seedling growth

This study identifies amyloid and amyloid-like structures in plant seed storage protein bodies (SSPB) and demonstrates their role in controlling germination and seedling growth.

Using a recently approved tumor mutational burden biomarker to stratify patients for immunotherapy may introduce a sex bias

The paper investigates if using a high tumor mutational burden (TMB) threshold for immunotherapy selection introduces sex bias, finding significant bias in melanoma but not in other cancers.

Immune determinants of the association between tumor mutational burden and immunotherapy response across cancer types

The paper investigates how immune factors influence the predictive power of tumor mutational burden (TMB) for immunotherapy response across cancer types.

In-vivo protein nitration and de-nitration facilitate Vibrio cholerae cell survival under anaerobic condition: Consequences of Nitrite induced protein nitration

This study shows that in vivo protein nitration and denitration in Vibrio cholerae under anaerobic conditions enhance cell survival by managing nitrite and nitrate levels.

Discerning amyloid network in plants

The paper identifies a mesh-like amyloid network in plant seeds using Congo red staining, showing apple-green birefringence, and hypothesizes its composition includes proteins and carbohydrates.

Leaf form diversification in an heirloom tomato results from alterations in two different HOMEOBOX genes

The paper identifies two HOMEOBOX gene alterations responsible for leaf form diversity in heirloom tomatoes.

Regeneration of lung epithelial cells by Fullerene C60 nanoformulation: A possible treatment strategy for acute respiratory distress syndrome (ARDS)

This paper demonstrates that a Fullerene C60 nanoformulation can regenerate lung epithelial cells exposed to apoptosis-inducing molecules, suggesting its potential as a treatment for ARDS.

Accelerated tissue repair through cell proliferative effect by a size controlled aqueous based Fullerene C60 nanoformulation

The paper develops a size-controlled aqueous Fullerene C60 nanoformulation that promotes cell proliferation and tissue repair in cellular and animal models.

Higher prevalence of homologous recombination-deficiency in lung squamous carcinoma from African Americans

The paper compares genomic features between African American and European American lung cancers, finding higher genomic instability and homologous recombination-deficiency in African American tumors.

Effects of Temperatures and High Pressures on the Growth and Survivability of Methanogens and Stable Carbon Isotope Fractionation: Implications for Deep Subsurface Life on Mars

This study examines the effects of temperature and pressure on Methanothermobacter wolfeii's growth, carbon isotopic fractionation, and morphology, suggesting its potential survival under Martian subsurface conditions.

Decoding the gene co-expression network underlying the ability of Gevuina avellana Mol. to live in diverse light conditions

The paper identifies a gene co-expression network in Gevuina avellana that supports its ability to maintain optimal photosynthetic performance across diverse light conditions.

Profiling of accessible chromatin regions across multiple plant species and cell types reveals common gene regulatory principles and new control modules

The paper uses ATAC-seq to profile accessible chromatin regions in multiple plant species and cell types, identifying conserved gene regulatory principles and new control modules.