K. Aldape

Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas

This study investigates the relationship between CDKN2A mRNA expression and clinical outcomes in meningiomas, finding that high expression is associated with poorer progression-free survival and more aggressive tumor characteristics.

Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways

The paper identifies shared molecular features between H3K27M diffuse midline gliomas and PFA ependymomas, linking them to hindbrain developmental pathways.

Prediction of cancer treatment response from histopathology images through imputed transcriptomics

ENLIGHT-DeepPT predicts cancer treatment response from H&E slides by first imputing transcriptomics and then using that data to predict response across multiple therapies and cancer types.

Sex biases in cancer and autoimmune disease incidence are strongly positively correlated with mitochondrial gene expression across human tissues

Using a recently approved tumor mutational burden biomarker to stratify patients for immunotherapy may introduce a sex bias

The paper investigates if using a high tumor mutational burden (TMB) threshold for immunotherapy selection introduces sex bias, finding significant bias in melanoma but not in other cancers.

Immune determinants of the association between tumor mutational burden and immunotherapy response across cancer types

The paper investigates how immune factors influence the predictive power of tumor mutational burden (TMB) for immunotherapy response across cancer types.

Cross-species identification of cancer-resistance associated genes uncovers their relevance to human cancer risk

The paper identifies cancer-resistance associated genes across species and finds their relevance to human cancer risk through conservation analysis and functional studies.

Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial ependymoma

The paper identifies a novel subset of supratentorial ependymomas in children characterized by recurrent PLAGL1 fusions and distinct molecular features.

DNA methylation and survival differences associated with the type of IDH mutation in 1p/19q non-codeleted astrocytomas

The paper shows that IDH mutations other than p.R132H in 1p/19q non-codeleted astrocytomas are linked to higher DNA methylation and better patient survival.

A simple, high-throughput method of protein and label removal from extracellular vesicle samples

This paper develops a high-throughput method to remove excess fluorescent labels from extracellular vesicle samples, improving flow cytometric analysis.

Whole exome precision oncology targeting synthetic lethal vulnerabilities across the tumor transcriptome

This paper predicts patient response to cancer therapies using computationally derived genetic interactions across multiple tumor transcriptomics datasets.