p16-dependent upregulation of PD-L1 impairs immunosurveillance of senescent cells
J. Majewska, A. Agrawal, A. Mayo, L. Roitman, R. Chatterjee, J. Kralova, T. Landsberger, Y. Katzenelenbogen, T. M. Salame, E. Hagai, N. Stanojevic, I. Amit, U. Alon, V. Krizhanovsky
This study identifies p16-dependent upregulation of PD-L1 in senescent cells as a mechanism to evade immune clearance, showing that anti-PD-L1 treatment can eliminate these cells.
bioRxiv · Jan 30, 2023 · PreprintCell Biology