I. Amit

p16-dependent upregulation of PD-L1 impairs immunosurveillance of senescent cells

This study identifies p16-dependent upregulation of PD-L1 in senescent cells as a mechanism to evade immune clearance, showing that anti-PD-L1 treatment can eliminate these cells.

MYCN mediates cysteine addiction and sensitizes to ferroptosis

This study shows MYCN promotes cysteine addiction and ferroptosis resistance in neuroblastoma, identifying therapeutic targets for ferroptosis induction.

Physically interacting beta-delta pairs in the regenerating pancreas revealed by single cell sequencing

The paper uses single-cell RNA-sequencing to identify physically interacting beta-delta cell pairs in the regenerating pancreas and finds they provide stress protection during regeneration.

Single Cell Analysis of Regions of Interest (SCARI) using a novel photoswitchable tag

The paper introduces a photoswitchable tag technology to isolate and analyze live cells from specific regions in complex tissues, enabling spatially defined single-cell RNA sequencing.

Clump sequencing exposes the spatial expression programs of intestinal secretory cells

ClumpSeq reconstructs spatial atlases of rare intestinal cell types by sequencing small clumps of attached cells and inferring their position along the crypt-villus axis.

Cancer-associated fibroblast compositions change with breast cancer progression linking S100A4 and PDPN ratios with clinical outcome

The paper tracks changes in cancer-associated fibroblast (CAF) subpopulations during breast cancer progression, linking their ratios to clinical outcomes and BRCA mutations.

Lgr5+ telocytes are a signaling hub at the intestinal villus tip

The paper identifies Lgr5+ telocytes at the intestinal villus tip as signaling hubs that regulate epithelial gene zonation through Bmp and Wnt5a signals.