Author

N. Tarrats

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:development & morphogenesis· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

J. C. Acosta· 3 shared P. Hari· 3 shared A. Quintanilla· 2 shared F. R. Millar· 2 shared J. Birch· 2 shared J. F. Passos· 2 shared M. Muir· 2 shared V. G. Brunton· 2 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCell Biology

J. C. Acosta

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3 papers

Recent·Most cited

Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence.

I. Fernandez Duran, N. Tarrats, J. Birch, P. Hari, F. R. Millar, M. Muir, A. Quintanilla, V. G. Brunton, J. F. Passos, J. C. Acosta

This study shows that caspase-4 non-canonical inflammasome activation by LPS induces cellular senescence and contributes to oncogene-induced senescence and tumour suppression.

bioRxiv · Oct 16, 2020Cell Biology

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype.

P. Hari, F. R. Millar, N. Tarrats, J. Birch, C. J. Rink, I. Fernandez-Duran, M. Muir, A. J. Finch, V. G. Brunton, J. F. Passos, J. P. Morton, L. Boulter, J. C. Acosta

This study identifies TLR2 as a key mediator of oncogene-induced senescence by promoting cell cycle arrest and regulating the senescence-associated secretory phenotype through DAMPs.

Science Advances · Jun 1, 2019Peer-reviewedCell Biology

Inhibition of the 60S ribosome biogenesis GTPase LSG1 causes endoplasmic reticular disruption and cellular senescence

A. Pantazi, A. Quintanilla, P. Hari, N. Tarrats, E. Parasyraki, F. L. Dix, J. Patel, T. Chandra, J. C. Acosta, A. Finch

This study shows that inhibiting LSG1, a GTPase involved in 60S ribosome biogenesis, induces cellular senescence through ER disruption and cholesterol biosynthesis upregulation, with potential therapeutic implications.

bioRxiv · Nov 8, 2018Cancer Biology