L. Boulter

Thymic epithelial cell fate and potency in early organogenesis assessed by single cell transcriptional and functional analysis.

The paper uses single-cell RNA sequencing to analyze thymic epithelial cell fate and potency in early mouse thymus development, revealing sublineage-primed progenitors and functional bipotency changes.

Primary cilia loss promotes reactivation of morphogenesis and cyst-fission through a deregulated TGFβ-ECM-Integrin axis in polycystic liver disease.

The paper shows that loss of primary cilia in adult mouse bile duct cells leads to cyst formation via a fibronectin-rich microenvironment and a novel cyst-fission process, which can be inhibited by targeting a specific integrin receptor.

In vivo modelling of patient genetic heterogeneity identifies concurrent Wnt and PI3K activity as a potent driver of invasive cholangiocarcinoma growth.

This study identifies concurrent Wnt and PI3K activity as drivers of invasive cholangiocarcinoma growth and shows that their co-inhibition slows tumor growth in vivo.

Toll-like receptor 2 orchestrates a potent anti-tumor response in non-small cell lung cancer

This study identifies TLR2 as a tumor suppressor in early-stage lung cancer, showing its role in immune surveillance and tumor growth reduction through synthetic agonist administration.

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype.

This study identifies TLR2 as a key mediator of oncogene-induced senescence by promoting cell cycle arrest and regulating the senescence-associated secretory phenotype through DAMPs.