Author

A. Quintanilla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

J. C. Acosta· 4 shared P. Hari· 3 shared F. R. Millar· 2 shared M. Muir· 2 shared N. Tarrats· 2 shared A. Finch· 1 shared A. H. Sims· 1 shared A. Meynert· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersCancer Biology

J. C. Acosta

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Author profile →

4 papers

Recent·Most cited

Discovery of new senolytics using machine learning

V. Smer-Barreto, A. Quintanilla, R. J. Elliot, J. C. Dawson, J. Sun, N. Carragher, J. C. Acosta, D. A. Oyarzun

This paper uses machine learning to discover three new senolytic compounds by screening FDA-approved drugs and clinical candidates.

bioRxiv · Apr 26, 2022 · PreprintCancer Biology

Toll-like receptor 2 orchestrates a potent anti-tumor response in non-small cell lung cancer

F. R. Millar, A. Pennycuick, M. Muir, A. Quintanilla, P. Hari, E. Freyer, P. Gautier, A. Meynert, V. H. Teixeira, J. Connelly, W. A. Wallace, A. H. Sims, M. C. Frame, L. Boulter, S. M. Janes, , J. C. Acosta

This study identifies TLR2 as a tumor suppressor in early-stage lung cancer, showing its role in immune surveillance and tumor growth reduction through synthetic agonist administration.

bioRxiv · Jun 4, 2021 · PreprintCancer Biology

Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence.

I. Fernandez Duran, N. Tarrats, J. Birch, P. Hari, F. R. Millar, M. Muir, A. Quintanilla, V. G. Brunton, J. F. Passos, J. C. Acosta

This study shows that caspase-4 non-canonical inflammasome activation by LPS induces cellular senescence and contributes to oncogene-induced senescence and tumour suppression.

bioRxiv · Oct 16, 2020Cell Biology

Inhibition of the 60S ribosome biogenesis GTPase LSG1 causes endoplasmic reticular disruption and cellular senescence

A. Pantazi, A. Quintanilla, P. Hari, N. Tarrats, E. Parasyraki, F. L. Dix, J. Patel, T. Chandra, J. C. Acosta, A. Finch

This study shows that inhibiting LSG1, a GTPase involved in 60S ribosome biogenesis, induces cellular senescence through ER disruption and cholesterol biosynthesis upregulation, with potential therapeutic implications.

bioRxiv · Nov 8, 2018Cancer Biology