V. G. Brunton

A novel ILK/STAT3 pathway controls plasticity in a neural stem cell model of glioblastoma.

This study identifies a novel ILK-STAT3 pathway that regulates phenotypic plasticity and mesenchymal state in mouse glioblastoma stem cells.

SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells

This study identifies SKOR1 as a mediator of FER kinase-dependent breast cancer progression and suggests FER inhibition as a therapeutic strategy.

Characterisation of a nucleo-adhesome

The paper identifies a nucleo-adhesome, showing that adhesion proteins localize to the nucleus and regulate transcription through interactions like FAK and Hic-5.

11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis

This study investigates the effect of 11β-HSD1 inhibition on tumour growth and angiogenesis in murine models, finding increased SCC tumour growth but no effect on angiogenesis.

Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence.

This study shows that caspase-4 non-canonical inflammasome activation by LPS induces cellular senescence and contributes to oncogene-induced senescence and tumour suppression.

Identification of stromal genes differentially expressed in lobular breast cancer highlights role for pregnancy-associated-plasma protein-A

The paper identifies stromal genes differentially expressed in lobular breast cancer, highlighting pregnancy-associated-plasma protein-A (PAPPA) as a potential prognostic marker.

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype.

This study identifies TLR2 as a key mediator of oncogene-induced senescence by promoting cell cycle arrest and regulating the senescence-associated secretory phenotype through DAMPs.