N. W. Harper

Calcineurin promotes adaptation to chronic stress through two distinct mechanisms

This study shows calcineurin (CN) helps yeast adapt to chronic stress through two distinct mechanisms involving Crz1 and Crz1-independent pathways.

p53 controls choice between apoptotic and non-apoptotic death following DNA damage

This study shows p53 regulates whether DNA damage triggers apoptosis or non-apoptotic death, revealing that p53-deficient cells die via MPT-driven necrosis due to high basal respiration.