Immune-Mediated Necrotic Cell Death Initiated by Stressed Cardiomyocytes is a Major Contributor to Cardiomyocyte Loss Following Myocardial Infarction
Tin Soe Kyaw, Peter Kanellakis, Anne Le, Yi Ee Lye, Pranjal Patel, Kurt Brassington, Nalin Dayawanmsa, Hericka Bruna Figueiredo Galvão, Grant Raymond Drummond, Christopher Graeme Sobey, Alex Bobik, K ouml nig Peter
This study shows that cytotoxic γδ-T cells contribute to cardiomyocyte death after myocardial infarction, and targeting STING and type I interferon pathways reduces infarct size.
bioRxiv · May 5, 2026 · PreprintImmunology