Author

Yi Ee Lye

Baker Heart and Diabetes Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Alex BobikiD· 2 shared Peter Kanellakis· 2 shared Tin Soe KyawiD· 2 shared Anh Cao· 1 shared Anne LeiD· 1 shared Ban‐Hock Toh· 1 shared Christopher Graeme SobeyiD· 1 shared Grant Raymond DrummondiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

Alex BobikORCID

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2 papers

Recent·Most cited

Immune-Mediated Necrotic Cell Death Initiated by Stressed Cardiomyocytes is a Major Contributor to Cardiomyocyte Loss Following Myocardial Infarction

Tin Soe Kyaw, Peter Kanellakis, Anne Le, Yi Ee Lye, Pranjal Patel, Kurt Brassington, Nalin Dayawanmsa, Hericka Bruna Figueiredo Galvão, Grant Raymond Drummond, Christopher Graeme Sobey, Alex Bobik, K ouml nig Peter

This study shows that cytotoxic γδ-T cells contribute to cardiomyocyte death after myocardial infarction, and targeting STING and type I interferon pathways reduces infarct size.

bioRxiv · May 5, 2026 · PreprintImmunology

CD27+ γδ T Cells Drive Plaque Instability in Advanced Atherosclerosis: Targeting CXCR3 for Therapeutic Intervention

Peter Kanellakis, Anh Cao, Yi Ee Lye, Ban‐Hock Toh, Alex Bobik, Tin Soe Kyaw

This study identifies CD27+ γδ T cells as key drivers of atherosclerotic plaque instability and shows that targeting CXCR3 with AMG487 improves plaque stability.

bioRxiv · Aug 19, 2025 · PreprintImmunology