Author

Naomi Mihira

RIKEN Center for Brain Science

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Organism:non-human primate· 1

Frequent Co-Authors

Takaomi C. SaidoiD· 4 shared Hiroki SasaguriiD· 3 shared Takashi SaitoiD· 3 shared Kaori SatoiD· 2 shared Kenichi NagataiD· 2 shared Misaki Sekiguchi· 2 shared Naoto WatamuraiD· 2 shared Ryo FujiokaiD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersNeuroscience

Takaomi C. SaidoORCID

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4 papers

Recent·Most cited

CXCL10 drives female-specific tau pathology progression and defines sex-dependent vulnerability in tauopathy model mice

Ryohei Uenishi, Rinna Kawata, Tatsuya Manabe, Yukio Matsuba, Naomi Mihira, Toru Takeo, Takaomi C. Saido, Masanori Hijioka, Takashi Saito

This study identifies CXCL10 as a driver of female-specific tau pathology progression in tauopathy model mice, revealing a sex-dependent mechanism independent of T cell or glial activation.

Journal of Neuroinflammation · Aug 5, 2026Peer-reviewedNeuroscience

Metabolic resistance of Abeta3pE-42, epitope of the anti-Alzheimer therapeutic antibody, donanemab.

Nobuhisa Iwata, Satoshi Tsubuki, Misaki Sekiguchi, Kaori Watanabe-Iwata, Yukio Matsuba, Naoko Kamano, Ryo Fujioka, Risa Takamura, Naoto Watamura, Naomasa Kakiya, Naomi Mihira, Takahiro Morito, Keiro Shirotani, David M. A. Mann, Andrew Robinson, , Takaomi C. Saido

This paper investigates the metabolic stability and deposition of A{beta}3pE-42, a target of the Alzheimer's antibody donanemab, showing it is more stable than other A{beta}X-42 species and accumulates with age.

Life Science Alliance · Sep 30, 2024Peer-reviewedNeuroscience

New App knock-in mice that accumulate wild-type human Aβ as rapidly as AppNL-G-F mice exhibit intensive cored plaque pathology and neuroinflammation.

Kaori Sato, Naoto Watamura, Ryo Fujioka, Naomi Mihira, Misaki Sekiguchi, Kenichi Nagata, Toshio Ohshima, Takashi Saito, Takaomi C. Saido, Hiroki Sasaguri

This paper introduces a new mouse model that accumulates wild-type human Aβ rapidly, showing more severe cored plaque pathology and neuroinflammation than existing models.

bioRxiv · Apr 30, 2021 · PreprintNeuroscience

A non-human primate model of familial Alzheimer's disease

Kenya Sato, Hiroki Sasaguri, Wakako Kumita, Takashi Inoue, Yoko Kurotaki, Kenichi Nagata, Naomi Mihira, Kaori Sato, Tetsushi Sakuma, Takashi Yamamoto, Michihira Tagami, Ri‐Ichiroh Manabe, Kokoro Ozaki, Yasushi Okazaki, Takaomi C. Saido, Erika Sasaki

This paper describes the creation of the first non-human primate model of familial Alzheimer's disease using genome editing to introduce a PSEN1 mutation associated with early-onset AD.

bioRxiv · Aug 24, 2020 · PreprintNeuroscience