Non-Coding Genetic Analysis Implicates Interleukin 18 Receptor Accessory Protein 3'UTR in Amyotrophic Lateral Sclerosis
Chen Eitan, Aviad Siany, Elad Barkan, Tsviya Olender, Kristel R. van Eijk, Matthieu Moisse, Sali M.K. Farhan, Yehuda Matan Danino, Eran Yanowski, Hagai Marmor-Kollet, Natalia Rivkin, Nancy‐Sarah Yacovzada, Shu‐Ting Hung, Johnathan Cooper‐Knock, Chien‐Hsiung Yu, , Eran Hornstein
The paper identifies non-coding variants in the IL18RAP 3'UTR that reduce ALS risk by modulating neuro-inflammation through NF-κB signaling in microglia.
bioRxiv · Jun 3, 2021 · PreprintNeuroscience