Systematic functional screening of chromatin factors identifies strong lineage and disease dependencies in normal and malignant haematopoiesis
David Lara‐Astiaso, Ainhoa Goñi‐Salaverri, Julen Mendieta-Esteban, Nisha Narayan, C Del Valle, T Gross, George Giotopoulos, Mar Navarro-Alonso, Jon Zazpe, Francesco P. Marchese, Natalia Torrea, Isabel A. Calvo, Cécile K. Lopez, Diego Alignani, A Lopez, , Brian J.P. Huntly
This study uses CRISPR screens and Perturb-Seq to analyze 550 chromatin factors in haematopoiesis and AML, revealing lineage-specific roles and therapeutic implications.
bioRxiv · Aug 11, 2022 · PreprintGenomics