Transcriptomic profiling reveals a pro-nociceptive role for Angiotensin II in inflammatory bowel disease
James P. Higham, Charity N. Bhebhe, Rohit A Gupta, Michael M. Tranter, Farah M. Barakat, Harween Dogra, Natalie Bab, Eva L. Woźniak, Katie H. Barker, Catherine H. Wilson, Charles A. Mein, Tim Raine, James J. Cox, John N. Wood, Nicholas Michael Croft, , David Colin Bulmer
This study identifies Angiotensin II as a pro-nociceptive mediator in IBD by showing increased Agt expression and AT1 receptor activation in colonic neurons.
Pain · Jan 29, 2024Peer-reviewedNeuroscience