James J. Cox

The study of differential expressions of MCPH and Seckel syndrome genes and their paralogues

This study examines the spatio-temporal expression patterns of MCPH and Seckel syndrome genes and their paralogues in mouse embryos to explore complementation and divergence in their regulation.

Analgesic targets identified in mouse sensory neuron somata and terminal pain translatomes

The paper identifies analgesic targets in mouse sensory neurons by analyzing translatomes in somata and terminals under different pain conditions.

Novel therapies for cancer-induced bone pain

This study evaluates three potential treatments for cancer-induced bone pain in mice, finding that dual inhibition of NGF and TNF significantly reduces pain-related behaviors.

Two distinct mechanisms for Nav1.7 null analgesia

The paper compares genetic and pharmacological loss-of-function mechanisms of Nav1.7 analgesia, highlighting distinct opioid-dependent and -independent pathways in embryonic and adult stages.

Transcriptomic profiling reveals a pro-nociceptive role for Angiotensin II in inflammatory bowel disease

This study identifies Angiotensin II as a pro-nociceptive mediator in IBD by showing increased Agt expression and AT1 receptor activation in colonic neurons.

Chemogenetic silencing of NaV1.8 positive sensory neurons reverses chronic neuropathic and bone cancer pain in FLEx PSAM4-GlyR mice

Molecular basis of FAAH-OUT-associated human pain insensitivity

The paper identifies how the FAAH-OUT lncRNA regulates FAAH expression through DNA methylation and enhancer activity, linking it to pain insensitivity.

The mechanism of analgesia in Nav1.7 null mutants

This study identifies opioid-dependent inhibition of neurotransmitter release as the primary mechanism of analgesia in NaV1.7 null mutants in mice and humans.

Sensory neuron-derived Nav1.7 contributes to dorsal horn neuron excitability

This study shows that Nav1.7 from sensory neurons affects dorsal horn neuron excitability, with functional effects not predicted by mRNA levels.

CRISPR interference at the FAAH-OUT genomic region reduces FAAH expression

The paper shows that CRISPR interference at the FAAH-OUT region reduces FAAH expression, supporting its role in regulating FAAH and suggesting therapeutic potential.

Mapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene targeted mice

The paper identifies 267 NaV1.7-associated proteins in mice using epitope-tagged gene targeting and mass spectrometry, including novel interactors validated by co-immunoprecipitation and functional assays.