The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 Bioactivation
L CHEN, Kaiden Thompson, Muntasir Kamal, Kateryna Sihuta, Irini Topalidou, Andrew R. Burns, Nazli H. Farshour, Brittany Cooke, Jessica J. Knox, Yanqing Jiang, Modhar Al Qasser, Ermira Shuteriqi, Matej Ušaj, Justin Ching, Arthur Flaget, , Peter John Roy
This study shows tioxazafen is bioactivated by cytochrome P450s into a proteasome disruptor, leading to toxicity in nematodes and potential human skin reactions.
bioRxiv · Jul 16, 2026 · PreprintPharmacology & Toxicology