Author
University of TorontoORCID 0000-0003-0675-2847Unclaimed ORCID profile · follow to get notified of new preprints
10 papers
Recent·Most cited
Myra Paz David Masinas, Athanasios Litsios, Matej Ušaj, Harsha Garadi Suresch, Charles M. Boone, Brenda Andrews
The paper expands TheCellVision.org repository with two new single-cell phenomics projects on yeast intracellular organization and DUB biology.
bioRxiv · Sep 3, 2026 · PreprintCell Biology
L CHEN, Kaiden Thompson, Muntasir Kamal, Kateryna Sihuta, Irini Topalidou, Andrew R. Burns, Nazli H. Farshour, Brittany Cooke, Jessica J. Knox, Yanqing Jiang, Modhar Al Qasser, Ermira Shuteriqi, Matej Ušaj, Justin Ching, Arthur Flaget, , Peter John Roy
This study shows tioxazafen is bioactivated by cytochrome P450s into a proteasome disruptor, leading to toxicity in nematodes and potential human skin reactions.
bioRxiv · Jul 16, 2026 · PreprintPharmacology & Toxicology
Ira Horecka, Matej Ušaj, Myra Paz David Masinas, Henry N. Ward, Xiang Zhang, Arshia Zernab Hassan, Maximilian Billmann, Hannes Luc Röst, Chad L. Myers, Michael Costanzo, Brenda Andrews, Charles M. Boone
The paper expands TheCellMap.org to include human genetic interactions from CRISPR-based analysis in HAP1 cells, enabling visualization and exploration of the network.
bioRxiv · Mar 18, 2026 · PreprintSystems Biology
Maximilian Billmann, Michael Costanzo, Mahfuzur Rahman, Katherine Chan, Amy H.Y. Tong, Henry N. Ward, Arshia Zernab Hassan, Xiang Zhang, Kevin R. Brown, Thomas Rohde, Angela Helen Shaw, Catherine Ross, Jolanda S. van Leeuwen, Michael Aregger, Keith A. Lawson, , Chad L. Myers
The paper develops a method to quantify genetic interactions from CRISPR-Cas9 screens and identifies systematic variations in screen data.
bioRxiv · Jun 30, 2025 · PreprintBioinformatics
Maximilian Billmann, Michael Costanzo, Xiang Zhang, Arshia Zernab Hassan, Mahfuzur Rahman, Kevin R. Brown, Katherine Chan, Amy H.Y. Tong, Carles Pons, Henry N. Ward, Catherine Ross, Jolanda S. van Leeuwen, Michael Aregger, Keith A. Lawson, Barbara Mair, , Charles M. Boone
The paper constructs a genome-scale genetic interaction network from 4 million double mutants in HAP1 cells, revealing conserved genetic network principles across species and uncovering novel gene functions and cancer dependencies.
bioRxiv · Jun 30, 2025 · PreprintSystems Biology
Sylvia Varland, Rui Duarte Silva, Ine Kjosås, Alexandra Faustino, Annelies Bogaert, Maximilian Billmann, Hadi Boukhatmi, Barbara Kellen, Michael Costanzo, Adrian Drazic, Camilla Osberg, Katherine Chan, Xiang Zhang, Amy H.Y. Tong, Simonetta Andreazza, , Thomas Arnesen
The paper shows that N-terminal acetylation by NatC protects proteins from degradation, enhancing longevity and motility, and that UBR4-KCMF1 targets unacetylated N-terminal Met followed by hydrophobic residues.
Nature Communications · Oct 27, 2023Peer-reviewedMolecular Biology
Anne-Laure Valton, Sergey V. Venev, Barbara Mair, Eraj Shafiq Khokhar, Amy H.Y. Tong, Matej Ušaj, Katherine Chan, Athma A. Pai, Jason Moffat, Job Dekker
The paper identifies three types of chromatin boundaries that regulate cohesin traffic, which guides enhancer-promoter interactions and affects gene regulation.
Nature Structural & Molecular Biology · Dec 1, 2022Peer-reviewedGenomics
Yuko Arita, Griffin Kim, Zhijian Li, Helena Friesen, Gina M. Turco, Rebecca Y. Wang, Dale Climie, Matej Ušaj, Manuel Hotz, Emily H. Stoops, Anastasia Baryshnikova, Charles M. Boone, David Botstein, Brenda Andrews, R. Scott McIsaac
The paper develops YETI, a yeast library with inducible gene expression, and shows low native expression can bias promoter-perturbing screens.
Molecular Systems Biology · Jun 1, 2021Peer-reviewedSynthetic Biology
Michael Aregger, Keith A. Lawson, Maximilian Billmann, Michael Costanzo, Amy H.Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Ušaj, Lucy Nedyalkova, Olga S. Sizova, Andrea Habsid, Judy Pawling, Zhen‐Yuan Lin, , Jason Moffat
This study maps genetic interactions in FASN-deficient cells to identify genes involved in lipid uptake and metabolic adaptation.
Nature Metabolism · Jun 1, 2020Peer-reviewedSystems Biology
Traver Hart, Amy H.Y. Tong, Katie Chan, Jolanda S. van Leeuwen, Ashwin Seetharaman, Michael Aregger, Megha Chandrashekhar, Nicole Hustedt, Sahil Seth, Avery J. C. Noonan, Andrea Habsid, Olga S. Sizova, Lyudmila Nedyalkova, Ryan Climie, Keith A. Lawson, , Jason Moffat
The paper evaluates CRISPR/Cas9 knockout screens in human cell lines and designs an optimized gRNA library to improve gene knockout efficiency and accuracy.
bioRxiv · Mar 16, 2017 · PreprintSystems Biology