The spliced leader RNA silencing (SLS) pathway in Trypanosoma brucei is induced by perturbations of endoplasmic reticulum, Golgi, or mitochondrial proteins factors and functional analysis of SLS inducing kinase, PK3
Uthman Okalang, Bar Mualem Bar-Ner, K. Shanmugha Rajan, Nehemya Friedman, Saurav Aryal, Katarina Egarmina, Ronen Hope, Netaly Khazanov, Hanoch Senderowitz, Assaf Alon, Deborah Fass, Shulamit Michaeli
The paper shows that the SLS pathway in Trypanosoma brucei is triggered by disruptions in ER, Golgi, or mitochondrial protein handling and identifies PK3 phosphorylation as critical for its activation.
mBio · Nov 30, 2021Peer-reviewedMolecular Biology