The paper identifies two distinct gene programs associated with disease tolerance and resistance in influenza virus infection using mouse strain data.

Cell Systems · Dec 1, 2022Peer-reviewedSystems Biology

The host transcriptional response to superinfection by influenza virus and streptococcus pneumonia

Ofir Cohn, Gal Yankovitz, Michal Mandelboim, Naama Peshes‐Yaloz, Eran Bacharach, Irit Gat‐Viks

This study identifies transcriptional changes in mice during influenza and pneumococcal superinfection, revealing rewired immune resistance programs and potential therapeutic targets.

bioRxiv · Aug 15, 2022 · PreprintSystems Biology

Remote immune processes revealed by immune-derived circulating cell-free DNA

Ilana Fox-Fisher, Sheina Piyanzin, Bracha-Lea Ochana, Agnes Klochendler, Judith Magenheim, Ayelet Peretz, Netanel Loyfer, Joshua Moss, Daniel Cohen, Yaron Drori, Nehemya Friedman, Michal Mandelboim, Marc E. Rothenberg, Julie M. Caldwell, Mark Rochman, , Yuval Dor

The paper uses immune cell type-specific methylation patterns in circulating cell-free DNA to monitor immune dynamics and find that immune-derived cfDNA levels reflect immune homeostasis and predict immune responses to perturbations.

eLife · Nov 26, 2021Peer-reviewedGenomics

Accurate in vivo population sequencing uncovers drivers of within-host genetic diversity in viruses

Maoz Gelbart, Sheri Harari, Ya’ara Ben-Ari, Talia Kustin, Dana G. Wolf, Michal Mandelboim, Orna Mor, Pleuni Simone Pennings, Adi Stern

AccuNGS detects rare viral variants in clinical samples, revealing differences in within-host genetic diversity among HIV, RSV, and CMV infections.

PLoS Pathogens · Nov 4, 2020Peer-reviewedEvolutionary Biology