Targeting the Mitochondrial ACSS1 Dependent Acetate and Pyrimidine Axis Suppresses Mantle Cell Lymphoma Progression
Johnvesly Basappa, Aaron R. Goldman, Cosimo Lobello, Shengchun Wang, David Rushmore, Olga Melnikov, Neil V. Sen, Vinay S. Mallikarjuna, Priyanka Jain, Masoud Edalati, David S. Nelson, Kathy Qi Cai, Pin Lu, Reza Nejati, Hossein Borghaei, , Mariusz A. Wasik
This paper identifies ACSS1 as a metabolic driver in lymphomas, showing its role in acetate-to-acetyl-CoA conversion and pyrimidine biosynthesis, and demonstrates that targeting ACSS1 suppresses tumor growth.
Cancer Letters · Apr 7, 2026Peer-reviewedCancer Biology