Author

Reza Nejati

Fox Chase Cancer CenterORCID 0000-0002-2188-156XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Assay:metabolomics· 2 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Mariusz A. WasikiD· 4 shared Aaron R. GoldmaniD· 3 shared Cosimo LobelloiD· 3 shared David RushmoreiD· 3 shared Johnvesly BasappaiD· 3 shared Kathy Qi CaiiD· 2 shared Kavindra NathiD· 2 shared Luca MologniiD· 2 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Mariusz A. WasikORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

A Novel ACLY Inhibitor Induces Transcriptional and Metabolic Reprogramming to Overcome Tyrosine kinase inhibitor Resistance in Lymphoma

Nagarajan Pattabiraman, Cosimo Lobello, David Rushmore, Shengchun Wang, Luca Mologni, Hossein Borgh, Kavindra Nath, Wujuan Zhang, Aaron R. Goldman, Reza Nejati, Mariusz A. Wasik, Johnvesly Basappa

This paper identifies VCB1, a novel ACLY inhibitor, which overcomes TKI resistance in lymphoma by disrupting lipid and nucleotide metabolism, ISR, and redox homeostasis.

bioRxiv · Oct 4, 2026 · PreprintCancer Biology

Tyrosine phosphorylation and dimerization cooperatively activate NAMPT to enable NAD+ synthesis in cancer

Johnvesly Basappa, Cosimo Lobello, Anneliese M. Faustino, Cristina Uribe‐Alvarez, David Rushmore, Niel Sen, Li Wang, Andrey Efimov, Kathy Qi Cai, Jaime Laurel Schneider, Lori A. Rink, Aaron N. Hata, Luca Mologni, Wujuan Zhang, Aaron R. Goldman, , Mariusz A. Wasik

This study identifies tyrosine phosphorylation and dimerization as cooperative mechanisms activating NAMPT, enhancing NAD+ synthesis and cancer cell growth.

bioRxiv · Aug 17, 2026 · PreprintCancer Biology

Targeting the Mitochondrial ACSS1 Dependent Acetate and Pyrimidine Axis Suppresses Mantle Cell Lymphoma Progression

Johnvesly Basappa, Aaron R. Goldman, Cosimo Lobello, Shengchun Wang, David Rushmore, Olga Melnikov, Neil V. Sen, Vinay S. Mallikarjuna, Priyanka Jain, Masoud Edalati, David S. Nelson, Kathy Qi Cai, Pin Lu, Reza Nejati, Hossein Borghaei, , Mariusz A. Wasik

This paper identifies ACSS1 as a metabolic driver in lymphomas, showing its role in acetate-to-acetyl-CoA conversion and pyrimidine biosynthesis, and demonstrates that targeting ACSS1 suppresses tumor growth.

Cancer Letters · Apr 7, 2026Peer-reviewedCancer Biology

Pol is a functional dependency and therapeutic vulnerability in DNMT3A deficient leukemia cells

Bac Viet Le, Umeshkumar M. Vekariya, Monika Maria Toma, Margaret Nieborowska-Skorska, Marie‐Christine Caron, Malgorzata Gozdecka, Zayd Haydar, Martin Walsh, Jayashri Ghosh, Elaine Vaughan‐Williams, Paulina Podszywalow‐Bartnicka, Anna-Mariya Kukuyan, Sylwia Ziółkowska, Jessica Atkins, Emir Hadzijusufovic, , Tomasz Skórski

This study identifies Polθ as a therapeutic target in DNMT3A-mutated leukemia by showing its essential role in DNA repair and replication fork restart, and demonstrates that its inhibition enhances standard therapies.

Cell Reports Medicine · Mar 1, 2026Peer-reviewedCancer Biology