Author

Nicholas A. Sambold

Arc Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Caroline M. WilsoniD· 2 shared Luke A. GilbertiD· 2 shared Abolfazl ArabiD· 1 shared Chris C.‐S. HsiungiD· 1 shared Daniel D. RichmaniD· 1 shared Greg C. PommieriD· 1 shared Jeffrey A. HussmanniD· 1 shared Jonathan S. WeissmaniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersSynthetic Biology

Caroline M. WilsonORCID

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2 papers

Recent·Most cited

Combinatorial effector targeting (COMET) for transcriptional modulation and locus-specific biochemistry

Caroline M. Wilson, Greg C. Pommier, Daniel D. Richman, Nicholas A. Sambold, Jeffrey A. Hussmann, Jonathan S. Weissman, Luke A. Gilbert

The paper introduces COMET, a high-throughput screening platform for identifying transcriptional modulators by testing combinatorial dCas9-based fusion proteins, and finds over 5800 significant hits that modulate transcription.

bioRxiv · Oct 28, 2024 · PreprintSynthetic Biology

Higher-order combinatorial chromatin perturbations by engineered CRISPR-Cas12a for functional genomics

Chris C.‐S. Hsiung, Caroline M. Wilson, Nicholas A. Sambold, R. Dai, Q. Chen, Noam Teyssier, Sara Misiukiewicz, Abolfazl Arab, Thomas A. O’Loughlin, Joshua C. Cofsky, Junwei Shi, Luke A. Gilbert

The paper introduces multiAsCas12a, an engineered CRISPR-Cas12a variant enabling higher-order combinatorial chromatin perturbations, and demonstrates its use in discovering new enhancer elements and dissecting cis-regulatory element functions.

Nature Biotechnology · May 17, 2024Peer-reviewedGenetics