Caroline M. Wilson

Scalable probe-based single-cell transcriptional profiling for virtual cell perturbation mapping and synthetic biology phenotyping

ProPer-seq is a cost-effective, barcode-free single-cell perturbation profiling method that enables scalable analysis of synthetic biology perturbations and reveals transcriptional control principles.

Combinatorial effector targeting (COMET) for transcriptional modulation and locus-specific biochemistry

The paper introduces COMET, a high-throughput screening platform for identifying transcriptional modulators by testing combinatorial dCas9-based fusion proteins, and finds over 5800 significant hits that modulate transcription.

Higher-order combinatorial chromatin perturbations by engineered CRISPR-Cas12a for functional genomics

The paper introduces multiAsCas12a, an engineered CRISPR-Cas12a variant enabling higher-order combinatorial chromatin perturbations, and demonstrates its use in discovering new enhancer elements and dissecting cis-regulatory element functions.

Acute and Chronic Molecular Signatures and Associated Symptoms of Blast Exposure in Military Breachers

This study identifies acute and chronic molecular changes in military breachers exposed to blast, showing transcriptional and inflammatory biomarkers for acute exposure and DNA methylation for chronic symptoms.