Author

Thomas A. O’Loughlin

University of California, San FranciscoORCID 0000-0002-4783-2352Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Abolfazl ArabiD· 1 shared Caroline M. WilsoniD· 1 shared Chris C.‐S. HsiungiD· 1 shared Joshua C. CofskyiD· 1 shared Junwei ShiiD· 1 shared Luke A. GilbertiD· 1 shared Nicholas A. Sambold· 1 shared Noam TeyssieriD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperGenetics

Abolfazl ArabORCID

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1 paper

Recent·Most cited

Higher-order combinatorial chromatin perturbations by engineered CRISPR-Cas12a for functional genomics

Chris C.‐S. Hsiung, Caroline M. Wilson, Nicholas A. Sambold, R. Dai, Q. Chen, Noam Teyssier, Sara Misiukiewicz, Abolfazl Arab, Thomas A. O’Loughlin, Joshua C. Cofsky, Junwei Shi, Luke A. Gilbert

The paper introduces multiAsCas12a, an engineered CRISPR-Cas12a variant enabling higher-order combinatorial chromatin perturbations, and demonstrates its use in discovering new enhancer elements and dissecting cis-regulatory element functions.

Nature Biotechnology · May 17, 2024Peer-reviewedGenetics