Jay Christopher Horvat

Microbiota Modulation Induces Elevated Duodenal Eosinophils Upon Gluten Exposure in Mice: Implications for Non-Coeliac Gluten Sensitivity

This study shows that antibiotic-induced microbiome modulation in mice alters immune responses to gluten, increasing duodenal eosinophils and activating epithelial γδ T-cells.

Crucial role for iron metabolism in mediating influenza A virus infection and associated disease

This study shows that iron metabolism influences influenza A virus infection and disease by altering gene expression, increasing viral titer, and worsening inflammation, with TFR1 inhibition offering protection.

The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease

This study investigates the effects of iron deficiency and overload on SARS-CoV-2 lung infection in mice, finding modest inflammatory changes but no significant disease exacerbation.

Autonomic regions of the brainstem show a sex-specific inflammatory response to systemic neonatal lipopolysaccharide

This study examines sex-specific inflammatory responses in brainstem autonomic regions following neonatal LPS exposure in rats, showing distinct effects at two timepoints.