Author

Nick van Bruggen

Calico Life Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:GWAS / association mapping· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Brandon J. WhitcheriD· 1 shared Bryan King· 1 shared Bryson D. BennettiD· 1 shared Caitlin F. ConnellyiD· 1 shared Carmela SidrauskiiD· 1 shared Chunlian ZhangiD· 1 shared Elena P. SorokiniD· 1 shared Elizabeth Louise ThomasiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenetics

Brandon J. WhitcherORCID

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2 papers

Recent·Most cited

eIF2B Activator Rescues Neonatal Lethality of an eIF2Bα Sugar Phosphate Binding Mutation Associated with Vanishing White Matter Disease

Karin Lin, Nina Ly, Rejani B. Kunjamma, Ngoc Vu, Bryan King, Holly M. Robb, Eric G. Mohler, Janani Sridar, Qi Hao, Jose Zavala‐Solorio, Chunlian Zhang, Varahram Shahryari, Nick van Bruggen, Caitlin F. Connelly, Bryson D. Bennett, , Carmela Sidrauski

This paper shows that an eIF2B activator rescues neonatal lethality in a VWM mouse model but leads to age-related motor deficits and myelin loss.

JCI Insight · Jul 15, 2025Peer-reviewedNeuroscience

Genetic architecture of 11 abdominal organ traits derived from abdominal MRI using deep learning

Yi Liu, Nicolas Basty, Brandon J. Whitcher, Jimmy David Bell, Elena P. Sorokin, Nick van Bruggen, Elizabeth Louise Thomas, Madeleine Cule

The paper uses deep learning to quantify abdominal organ traits from MRI scans and identifies genetic associations with organ health parameters.

bioRxiv · Jul 14, 2020 · PreprintGenetics