Potential combined pro-cognitive, anxiolytic and antidepressant properties of novel GABAA receptor positive modulators with preferential efficacy at the α5-subunit
Thomas D. Prevot, Guanguan Li, Aleksandra Vidojevic, Keith A. Misquitta, Corey Fee, Anja Santrac, Daniel E. Knutson, Michael R. Stephen, Revathi Kodali, Nicolas M. Zahn, Leggy A. Arnold, Petra Scholze, Janet L. Fisher, Bojan D. Marković, Mounira Banasr, , Etienne Sibille
This study identifies three novel GABAA receptor modulators that show anxiolytic, antidepressant, and pro-cognitive effects in mice, unlike diazepam.
bioRxiv · May 29, 2018 · PreprintPharmacology & Toxicology