Chronic administration of a positive allosteric modulator at the alpha5-GABAA receptor reverses age-related dendritic shrinkage
Thomas D. Prévot, Akiko Sumitomo, Toshifumi Tomoda, Daniel E. Knutson, Guanguan Li, James Minton Cook, Etienne L. Sibille
This study shows that chronic treatment with a 5-GABA-A receptor PAM increases dendritic length, spine count, and density in mice, suggesting potential for reversing age-related cognitive decline.
bioRxiv · Feb 28, 2020 · PreprintNeuroscience