Author

Sung-Soo Jang

Gladstone InstitutesORCID 0000-0002-1938-9752Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

John R. HuguenardiD· 2 shared Misha Y. ZilberteriD· 2 shared Seo Yeon YooniD· 2 shared Yadong HuangiD· 2 shared Alex R. Zhang· 1 shared Alexander A. Osypov· 1 shared Antara T. RaoiD· 1 shared Anton IvanoviD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

John R. HuguenardORCID

Author profile →

4 papers

Recent·Most cited

Neuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimers Disease Pathogenesis

Dennis R. Tabuena, Sung-Soo Jang, Brian P. Grone, Oscar Yip, Emily A Aery Jones, Jessica R. Blumenfeld, Zherui Liang, Rajkamalpreet S. Mann, Yaqiao Li, Deanna Necula, Nicole Koutsodendris, Antara T. Rao, Leonardo Ding, Alex R. Zhang, Yanxia Hao, , Misha Y. Zilberter

This study identifies early hippocampal network hyperexcitability in APOE4 mice, linked to Nell2 overexpression, and shows its role in AD pathogenesis.

Nature Aging · Apr 3, 2026Peer-reviewedNeuroscience

Reticular Thalamic Hyperexcitability Drives Autism Spectrum Disorder Behaviors in the Cntnap2 Model of Autism

Sung-Soo Jang, Fuga Takahashi, John R. Huguenard

This study identifies reticular thalamic hyperexcitability as a driver of ASD behaviors in Cntnap2 knockout mice and shows that targeting RT activity can alleviate these deficits.

Science Advances · Aug 20, 2025Peer-reviewedNeuroscience

Actions of the Anti-Seizure Drug Carbamazepine in the Thalamic Reticular Nucleus: Potential Mechanism of Aggravating Absence Seizures

Sung-Soo Jang, Nicole Agranonik, John R. Huguenard

This study investigates how carbamazepine (CBZ) affects thalamic reticular neurons, revealing it selectively inhibits their tonic firing and disrupts GABAergic transmission, which exacerbates absence seizures.

Proceedings of the National Academy of Sciences · Jul 31, 2025Peer-reviewedPhysiology

Aβ initiates brain hypometabolism and network dysfunction via NOX2 activation: a potential onset mechanism of Alzheimer's disease

Anton Malkov, Irina Yu. Popova, Anton Ivanov, Sung-Soo Jang, Seo Yeon Yoon, Alexander A. Osypov, Yadong Huang, Yuri Zilberter, Misha Y. Zilberter

Aβ1-42 induces brain hypometabolism, network hyperactivity, and behavioral changes via NOX2-mediated oxidative stress, suggesting a novel therapeutic target for Alzheimer's disease treatment.

Communications Biology · Sep 9, 2021Peer-reviewedNeuroscience