Benoit Coulombe

Discovery and characterization of a pancreatic β cell subpopulation expressing an unknown surface epitope through single cell proteomics

The paper uses single-cell proteomics to identify and characterize a subpopulation of pancreatic β cells expressing a novel surface epitope, revealing functional differences among subpopulations.

Investigating pancreatic β cell membrane epitopes using unbiased cell-based Fab-phage display

This study uses Fab-phage display and bioinformatics to identify and characterize Fabs binding to pancreatic β cell membrane epitopes in a hyperglycemic environment.

High-accuracy mapping of human and viral direct physical protein-protein interactions using the novel computational system AlphaFold-pairs

The paper introduces AlphaFold-pairs, a computational method to predict protein-protein interactions, validated on human and viral systems, revealing new interactions in SARS-CoV-2 and Influenza A virus.

Recurrent chromosomal translocations in sarcomas create a mega-complex that mislocalizes NuA4/TIP60 to Polycomb target loci

This study identifies recurrent chromosomal translocations in sarcomas that merge NuA4/TIP60 and PRC2 complexes, leading to mislocalization of chromatin marks and aberrant gene expression.