Author

Nikolina Bąbała

Leiden University Medical Center

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Immunology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1

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Bram van den BroekiD· 1 shared Eliza Mari Kwesi‐MaliepaardiD· 1 shared Elselien FrijlinkiD· 1 shared Elzo de WitiD· 1 shared Fred van LeeuweniD· 1 shared Heinz JacobsiD· 1 shared Jannie G. BorstiD· 1 shared Liesbeth HoekmaniD· 1 shared

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1 shared paperImmunology

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1 paper

Recent·Most cited

ImmunologyScience AdvancesPeer-reviewedDec 12, 2025

Histone methyltransferase DOT1L maintains identity and restricts cytotoxic potential of CD8 T cells

Muddassir Malik, Willem-Jan de Leeuw, Muhammad Assad Aslam…·Fred van Leeuwen

This study shows that DOT1L maintains CD8 T cell identity and restricts their cytotoxic potential by preventing NK-cell features and enhancing anti-tumor reactivity.

5 citations

mousebulk RNA-seq

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