Fred van Leeuwen

This study shows that DOT1L influences dendritic cell subset development and antigen presentation by modulating histone H3K79 methylation.

The paper investigates how Fpt1 is recruited to tRNA genes in budding yeast, revealing a dual role of TFIIIB and TFIIIC in its binding under different RNAPIII conditions.

This study shows that DOT1L maintains CD8 T cell identity and restricts their cytotoxic potential by preventing NK-cell features and enhancing anti-tumor reactivity.

This study shows that targeting DOT1L and EZH2 together disrupts the germinal center identity of GCB-DLBCL cells, leading to a cell-identity crisis and reduced tumor growth in vivo.

The paper identifies Fpt1 as a chromatin-associated regulator that promotes RNA Polymerase III eviction from tRNA genes in response to nutrient changes in yeast.

The paper uses dynamic epistasis analysis to show how chromatin remodeling factors and transcription factor binding regulate transcriptional bursting in budding yeast.

This study shows that DOT1L regulates chromatin reorganization and gene expression in male germ cells, leading to fertility defects in its absence.

The paper introduces Epi-Decoder, a DNA sequencing-based method to systematically identify and quantify the chromatin proteome of a specific genomic locus in budding yeast, revealing dynamic changes under replication stress.