Author

Willem-Jan de Leeuw

The Netherlands Cancer InstituteORCID 0000-0001-8172-6804Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Fred van LeeuweniD· 2 shared Muddassir MalikiD· 2 shared Natalie ProostiD· 2 shared Tibor van Welsem· 2 shared Alsya J. AffandiiD· 1 shared Anne MensinkiD· 1 shared Aru Z. Wang· 1 shared Bram van den BroekiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCell Biology

Fred van LeeuwenORCID

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2 papers

Recent·Most cited

Cell BiologyLife Science AlliancePeer-reviewedMar 18, 2026

Histone methyltransferase DOT1L differentially affects the development of dendritic cell subsets

Rianne G. Bouma, Willem-Jan de Leeuw, Aru Z. Wang…·Joke M. M. den Haan

This study shows that DOT1L influences dendritic cell subset development and antigen presentation by modulating histone H3K79 methylation.

1 citation

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologyScience AdvancesPeer-reviewedDec 12, 2025

Histone methyltransferase DOT1L maintains identity and restricts cytotoxic potential of CD8 T cells

Muddassir Malik, Willem-Jan de Leeuw, Muhammad Assad Aslam…·Fred van Leeuwen

This study shows that DOT1L maintains CD8 T cell identity and restricts their cytotoxic potential by preventing NK-cell features and enhancing anti-tumor reactivity.

5 citations

mousebulk RNA-seq

𝕏 PostBluesky