Author

Elselien Frijlink

Leiden University Medical CenterORCID 0000-0002-9249-8074Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Bram van den BroekiD· 1 shared Eliza Mari Kwesi‐MaliepaardiD· 1 shared Elzo de WitiD· 1 shared Fred van LeeuweniD· 1 shared Heinz JacobsiD· 1 shared Jannie G. BorstiD· 1 shared Liesbeth HoekmaniD· 1 shared Maxime KempersiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Bram van den BroekORCID

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1 paper

Recent·Most cited

Histone methyltransferase DOT1L maintains identity and restricts cytotoxic potential of CD8 T cells

Muddassir Malik, Willem-Jan de Leeuw, Muhammad Assad Aslam, Eliza Mari Kwesi‐Maliepaard, Teun van den Brand, Bram van den Broek, Maxime Kempers, Liesbeth Hoekman, Natalie Proost, Tibor van Welsem, Nikolina Bąbała, Elselien Frijlink, Elzo de Wit, Jannie G. Borst, Heinz Jacobs, Fred van Leeuwen

This study shows that DOT1L maintains CD8 T cell identity and restricts their cytotoxic potential by preventing NK-cell features and enhancing anti-tumor reactivity.

Science Advances · Dec 12, 2025Peer-reviewedImmunology