Author

Muhammad Assad Aslam

Bahauddin Zakariya UniversityORCID 0000-0003-1905-2583Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Fred van LeeuweniD· 2 shared Heinz JacobsiD· 2 shared Liesbeth HoekmaniD· 2 shared Ben MorrisiD· 1 shared Bram van den BroekiD· 1 shared Camiel GöbeliD· 1 shared Daan J. KloostermaniD· 1 shared Daniël de Groot· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

Fred van LeeuwenORCID

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2 papers

Recent·Most cited

ImmunologyScience AdvancesPeer-reviewedDec 12, 2025

Histone methyltransferase DOT1L maintains identity and restricts cytotoxic potential of CD8 T cells

Muddassir Malik, Willem-Jan de Leeuw, Muhammad Assad Aslam…·Fred van Leeuwen

This study shows that DOT1L maintains CD8 T cell identity and restricts their cytotoxic potential by preventing NK-cell features and enhancing anti-tumor reactivity.

5 citations

mousebulk RNA-seq

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Cancer BiologyBloodPeer-reviewedJan 10, 2025

Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of Diffuse Large B Cell Lymphoma

Camiel Göbel, Rachele Niccolai, Marnix H. P. de Groot…·Heinz Jacobs

This study shows that targeting DOT1L and EZH2 together disrupts the germinal center identity of GCB-DLBCL cells, leading to a cell-identity crisis and reduced tumor growth in vivo.

18 citationstop 1%

humanChIP-seq

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