Loss of the Y chromosome drives epigenetic and transcriptomic plasticity in lung adenocarcinoma
Kathleen Schlüter, Mei-Ju May Chen, Gizem Altun, Sergio Manzano-Sanchez, Dung-Chi Wu, Nan Zhang, Ofir Griess, Luc Husemann, Fabian Bradic, Joseph Cornick, Nima Esmaeelpour, Oliver Mücke, Riccardo Moro, Katherine Kelly, Sara Chocarro, , Maria Llamazares Prada
This study shows that loss of the Y chromosome in lung adenocarcinoma causes epigenetic and transcriptomic changes that increase lineage plasticity and poor clinical outcomes.
bioRxiv · Jun 5, 2026 · PreprintCancer Biology