Author

Oliver Mücke

German Cancer Research Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Christoph PlassiD· 2 shared Pavlo LutsikiD· 2 shared Agata WilkiD· 1 shared Albert Fradera-SolaiD· 1 shared Albrecht StenzingeriD· 1 shared Alexander Schramm· 1 shared Angelika MerkeliD· 1 shared Antonella SarnataroiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Christoph PlassORCID

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2 papers

Recent·Most cited

Loss of the Y chromosome drives epigenetic and transcriptomic plasticity in lung adenocarcinoma

Kathleen Schlüter, Mei-Ju May Chen, Gizem Altun, Sergio Manzano-Sanchez, Dung-Chi Wu, Nan Zhang, Ofir Griess, Luc Husemann, Fabian Bradic, Joseph Cornick, Nima Esmaeelpour, Oliver Mücke, Riccardo Moro, Katherine Kelly, Sara Chocarro, , Maria Llamazares Prada

This study shows that loss of the Y chromosome in lung adenocarcinoma causes epigenetic and transcriptomic changes that increase lineage plasticity and poor clinical outcomes.

bioRxiv · Jun 5, 2026 · PreprintCancer Biology

Pipeline Olympics: continuable benchmarking of computational workflows for DNA methylation sequencing data against an experimental gold-standard

Yu‐Yu Lin, Kersten Breuer, Dieter Weichenhan, Pascal Lafrenz, Antonella Sarnataro, Agata Wilk, Maryna Chepeleva, Oliver Mücke, Maximilian Schönung, Franziska Petermann, Philip Reiner Kensche, Lena Weiser, Frank Thommen, Gideon Giacomelli, Karl J. V. Nordström, , Pavlo Lutsik

The paper benchmarks DNA methylation sequencing workflows against an experimental gold-standard, identifying superior workflows and developing a sustainable benchmarking platform.

Nucleic Acids Research · Sep 12, 2025Peer-reviewedBioinformatics