Evidence that the protein phosphatase activity of PTEN contributes to embryonic development and tumour suppression in mice
Priyanka Tibarewal, Laura Spinelli, Nisha Kriplani, Helen M. Wise, Nadège Poncet, Giulia Marzano, Karen E. Anderson, Katarzyna M. Grzes, Zofia Varyova, Mahreen Adil, C. Peter Downes, Phillip T. Hawkins, Len Stephens, Kate G. Storey, Doreen Ann Cantrell, , Nicholas R. Leslie
This study shows that PTEN's protein phosphatase activity is essential for embryonic development and tumor suppression in mice, as demonstrated by mutant mice with impaired protein phosphatase activity.
bioRxiv · Mar 17, 2026 · PreprintCancer Biology