Author

Mahreen Adil

University College LondonORCID 0000-0002-9222-5041Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Bart VanhaesebroeckiD· 2 shared Nicholas R. LeslieiD· 2 shared Nisha Kriplani· 2 shared Priyanka TibarewaliD· 2 shared Zofia VaryovaiD· 2 shared Adriana Alves· 1 shared Adrienne Margaret FlanaganiD· 1 shared C. Peter Downes· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Bart VanhaesebroeckORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Evidence that the protein phosphatase activity of PTEN contributes to embryonic development and tumour suppression in mice

Priyanka Tibarewal, Laura Spinelli, Nisha Kriplani, Helen M. Wise, Nadège Poncet, Giulia Marzano, Karen E. Anderson, Katarzyna M. Grzes, Zofia Varyova, Mahreen Adil, C. Peter Downes, Phillip T. Hawkins, Len Stephens, Kate G. Storey, Doreen Ann Cantrell, , Nicholas R. Leslie

This study shows that PTEN's protein phosphatase activity is essential for embryonic development and tumor suppression in mice, as demonstrated by mutant mice with impaired protein phosphatase activity.

bioRxiv · Mar 17, 2026 · PreprintCancer Biology

A mouse model of PTEN Hamartoma Tumour Syndrome reveals that loss of the nuclear function of PTEN drives macrocephaly, lymphoid overgrowth, and late-onset cancer

Priyanka Tibarewal, Victoria Rathbone, Sarah E. Conduit, Gala Anastasia Electra Classen, Fiona Black, Mohammad Amin Danesh, Georgia Constantinou, Zeinab Asgarian, Koujiro Tohyama, Nisha Kriplani, Virginia Alvarez Garcia, Elizabeth Foxall, Djenat Belarbi, Marie Leverve, Wayne P Pearce, , Bart Vanhaesebroeck

This study shows that a specific PTEN mutation causes macrocephaly, lymphoid overgrowth, and late-onset cancer in mice by impairing nuclear PTEN functions, while maintaining normal PI3K/AKT signaling.

Disease Models & Mechanisms · Nov 11, 2025Peer-reviewedGenetics