Nuclear GAPDH in cortical microglia mediates stress-induced cognitive inflexibility
Adriana Ramos, Koko Ishizuka, Ho Namkung, Lindsay N. Hayes, Atsushi Saito, Arisa Hayashida, Rupali Srivastava, Noah Elkins, Trexy Palen, Elisa Carloni, Tsuyoshi Tsujimura, Coleman B. Calva, Satoshi Ikemoto, Rana Rais, Barbara Stauch Slusher, , Akira Sawa
This study identifies the nuclear GAPDH cascade in microglia as a mediator of stress-induced cognitive inflexibility and shows that targeting it can normalize cognitive deficits.
bioRxiv · Jun 21, 2022 · PreprintMolecular Biology