Author

Rupali Srivastava

Johns Hopkins UniversityORCID 0000-0002-9351-5622Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Akira SawaiD· 4 shared Koko Ishizuka· 4 shared Atsushi SaitoiD· 3 shared Ho NamkungiD· 3 shared Adriana RamosiD· 2 shared Brian J. LeeiD· 2 shared Elisa CarloniiD· 2 shared Hanna Jaaro-PelediD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Akira SawaORCID

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4 papers

Recent·Most cited

Astrocyte redox imbalance underlies prelimbic neuronal hypoactivity and affective behavior in epilepsy

Travis E. Faust, Atsushi Saito, Shoichi Ishikawa, Kun Yang, Wendy Xin, Ho Namkung, Amit Agarwal, Adriana Ramos, Brian J. Lee, Lindsay Hayes, Rupali Srivastava, Sunday Adelakun, Sneha Saha, Trexy Palen, Tyler V. Cash-Padgett, , Akira Sawa

This study shows that astrocyte redox imbalance causes neuronal hypoactivity and affective behaviors in epilepsy, distinct from seizure mechanisms.

bioRxiv · Jan 31, 2026 · PreprintNeuroscience

Attenuated CaV1.2-BK channel protein interaction in bipolar disorder

Rupali Srivastava, Nathaniel Genduso, Koko Ishizuka, Akira Sawa

The paper identifies attenuated CaV1.2-BK channel protein interaction in bipolar disorder patients and shows its role in intracellular calcium dynamics and cycling behavior.

bioRxiv · Aug 8, 2025 · PreprintNeuroscience

The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorder

Ho Namkung, Hiroshi Yukitake, Daisuke Fukudome, Brian J. Lee, Mengnan Tian, Gianluca Ursini, Atsushi Saito, Shravika Lam, Suvarnambiga Kannan, Rupali Srivastava, Minae Niwa, Kamal Sharma, Peter P. Zandi, Hanna Jaaro-Peled, Koko Ishizuka, , Akira Sawa

This study identifies the miR-124-AMPAR pathway as a common mediator linking polygenic risks to shared behavioral changes in schizophrenia and bipolar disorder.

Neuron · Nov 14, 2022Peer-reviewedNeuroscience

Nuclear GAPDH in cortical microglia mediates stress-induced cognitive inflexibility

Adriana Ramos, Koko Ishizuka, Ho Namkung, Lindsay N. Hayes, Atsushi Saito, Arisa Hayashida, Rupali Srivastava, Noah Elkins, Trexy Palen, Elisa Carloni, Tsuyoshi Tsujimura, Coleman B. Calva, Satoshi Ikemoto, Rana Rais, Barbara Stauch Slusher, , Akira Sawa

This study identifies the nuclear GAPDH cascade in microglia as a mediator of stress-induced cognitive inflexibility and shows that targeting it can normalize cognitive deficits.

bioRxiv · Jun 21, 2022 · PreprintMolecular Biology