Author

Trexy Palen

Johns Hopkins UniversityORCID 0000-0002-2374-9474Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Adriana RamosiD· 2 shared Akira SawaiD· 2 shared Atsushi SaitoiD· 2 shared Elisa CarloniiD· 2 shared Ho NamkungiD· 2 shared Koko Ishizuka· 2 shared Rupali SrivastavaiD· 2 shared Amit AgarwaliD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersNeuroscience

Adriana RamosORCID

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2 papers

Recent·Most cited

Astrocyte redox imbalance underlies prelimbic neuronal hypoactivity and affective behavior in epilepsy

Travis E. Faust, Atsushi Saito, Shoichi Ishikawa, Kun Yang, Wendy Xin, Ho Namkung, Amit Agarwal, Adriana Ramos, Brian J. Lee, Lindsay Hayes, Rupali Srivastava, Sunday Adelakun, Sneha Saha, Trexy Palen, Tyler V. Cash-Padgett, , Akira Sawa

This study shows that astrocyte redox imbalance causes neuronal hypoactivity and affective behaviors in epilepsy, distinct from seizure mechanisms.

bioRxiv · Jan 31, 2026 · PreprintNeuroscience

Nuclear GAPDH in cortical microglia mediates stress-induced cognitive inflexibility

Adriana Ramos, Koko Ishizuka, Ho Namkung, Lindsay N. Hayes, Atsushi Saito, Arisa Hayashida, Rupali Srivastava, Noah Elkins, Trexy Palen, Elisa Carloni, Tsuyoshi Tsujimura, Coleman B. Calva, Satoshi Ikemoto, Rana Rais, Barbara Stauch Slusher, , Akira Sawa

This study identifies the nuclear GAPDH cascade in microglia as a mediator of stress-induced cognitive inflexibility and shows that targeting it can normalize cognitive deficits.

bioRxiv · Jun 21, 2022 · PreprintMolecular Biology