Visualizing the metazoan proliferation-terminal differentiation decision in vivo
Rebecca C. Adikes, Abraham Q. Kohrman, Michael A. Q. Martinez, Nicholas J. Palmisano, Jayson J. Smith, Taylor N. Medwig-Kinney, Mingwei Min, Maria D. Sallee, Ononnah B. Ahmed, Nuri Kim, Simeiyun Liu, Robert D. Morabito, Nicholas Weeks, Qinyun Zhao, Wan Zhang, , David Q. Matus
The paper introduces a CDK sensor to distinguish cycling cells from terminally differentiated cells in C. elegans and zebrafish, revealing commitment points and stochasticity in cell cycle control.
bioRxiv · Dec 18, 2019 · PreprintDevelopmental Biology