Wan Zhang

This study shows that cell cycle perturbation allows post-mitotic cells to maintain invasive behavior without exiting the cell cycle.

The paper introduces NanoDam, a method for tissue-specific transcription factor profiling in C. elegans using endogenous GFP-tagged TFs and nanobody-Dam fusions, identifying novel targets in specific cell types.

The paper investigates how NHR-67 and Groucho regulate the switch between proliferative and invasive states in C. elegans uterine cells.

This paper introduces a FLP-ON::TIR1 system for precise spatiotemporal protein degradation in C. elegans, showing it can drive efficient target protein degradation in specific cell types.

The paper reevaluates the relationship between EGL-43 and LIN-12 in C. elegans anchor cell invasion using a novel co-expression system and finds that LIN-12 is not required for AC proliferation after EGL-43 loss.

The paper shows that BAF and PBAF SWI/SNF complexes differentially regulate cell cycle arrest and invasion in C. elegans anchor cells.

The paper introduces new tools for the auxin-inducible degron system in C. elegans, enabling conditional protein depletion through CRISPR/Cas9-mediated genome editing.

The paper introduces a CDK sensor to distinguish cycling cells from terminally differentiated cells in C. elegans and zebrafish, revealing commitment points and stochasticity in cell cycle control.

The paper identifies a gene regulatory network in C. elegans anchor cell invasion, showing how transcription factors function differently before and after specification.