David Q. Matus

The paper systematically maps the localization of 49 actin-binding proteins during C. elegans gastrulation to understand their roles in apical constriction.

The paper introduces MOSAIC, a multimodal adaptive optical microscope that enables non-invasive imaging across biological scales in live specimens.

The paper develops mRNAbow, a system for generating low-toxicity mRNAs for multiplexed fluorescent imaging in diverse cellular and organismal systems.

This study shows that cell cycle perturbation allows post-mitotic cells to maintain invasive behavior without exiting the cell cycle.

This paper introduces a paintbrush method that significantly increases C. elegans microinjection efficiency by improving injection speed and survival rates.

The paper introduces NanoDam, a method for tissue-specific transcription factor profiling in C. elegans using endogenous GFP-tagged TFs and nanobody-Dam fusions, identifying novel targets in specific cell types.

The paper investigates how NHR-67 and Groucho regulate the switch between proliferative and invasive states in C. elegans uterine cells.

The paper identifies mutations in E3 ubiquitin ligases that restore development in SWI/SNF mutants in C. elegans, suggesting potential therapeutic targets for human developmental disorders.

This paper introduces a FLP-ON::TIR1 system for precise spatiotemporal protein degradation in C. elegans, showing it can drive efficient target protein degradation in specific cell types.

The paper describes a mounting protocol for live imaging of C. elegans larvae and adults using light sheet fluorescence microscopy.

The paper reevaluates the relationship between EGL-43 and LIN-12 in C. elegans anchor cell invasion using a novel co-expression system and finds that LIN-12 is not required for AC proliferation after EGL-43 loss.

The paper shows that BAF and PBAF SWI/SNF complexes differentially regulate cell cycle arrest and invasion in C. elegans anchor cells.

The paper introduces an engineered auxin analog and AtTIR1(F79G) pair to improve the specificity and efficacy of the auxin degradation system in C. elegans.

The paper introduces new tools for the auxin-inducible degron system in C. elegans, enabling conditional protein depletion through CRISPR/Cas9-mediated genome editing.

The paper introduces a CDK sensor to distinguish cycling cells from terminally differentiated cells in C. elegans and zebrafish, revealing commitment points and stochasticity in cell cycle control.

The paper identifies a gene regulatory network in C. elegans anchor cell invasion, showing how transcription factors function differently before and after specification.

This paper improves the AID system in C. elegans for single-cell protein degradation using NAA and demonstrates its application in developmental studies.

The paper develops a method to image subcellular dynamics in vivo using lattice light sheet microscopy and adaptive optics, revealing phenotypic diversity across organisms and developmental stages.