Jessica L. Feldman

Reciprocal E-cadherin signaling aligns apical surfaces between neighboring epithelial tissues to complete the C. elegans digestive tract

This study identifies the rectal valve cells in C. elegans that use E-cadherin signaling to align apical surfaces between the intestine and rectum, completing the digestive tract.

Inactivation of microtubule organizing center function of the centrosome is required for neuronal development and centriole elimination

The paper shows that inactivating centrosome function is necessary for neuronal differentiation by affecting cell morphology and dendrite development in C. elegans.

Dynamic remodeling of centrioles and the microtubule cytoskeleton in the lifecycle of chytrid fungi

The paper studies centriole and microtubule cytoskeleton remodeling in chytrid fungi during their lifecycle using bioinformatics, RNA sequencing, and expansion microscopy.

Somatic polyploidy supports biosynthesis and tissue function by increasing transcriptional output

The paper shows that polyploidy in C. elegans intestine increases transcriptional output and supports biosynthesis by compensating for mRNA dilution through increased RNA Polymerase II loading.

E-cadherin/HMR-1 and PAR-3 break symmetry at stable cell contacts in a developing epithelium

The paper identifies a mechanism by which intestinal cells in C. elegans break symmetry through PAR-3 and HMR-1 at stable cell contacts, establishing tissue-wide polarity.

Apical PAR complex proteins protect against epithelial assaults to create a continuous and functional intestinal lumen

The paper shows that apical PAR complex proteins are essential for maintaining epithelial integrity during intestinal development in C. elegans by preventing gaps that block the lumen.

Visualizing the metazoan proliferation-terminal differentiation decision in vivo

The paper introduces a CDK sensor to distinguish cycling cells from terminally differentiated cells in C. elegans and zebrafish, revealing commitment points and stochasticity in cell cycle control.