TTLL6-mediated Polyglutamylation of PurA Maintains Colonic Crypt Integrity
Vanessa Pires, Chloé Pangault, Conception Paul, Pascal Finetti, François Bertucci, Émilie Mamessier, Célia Jardin, Nuttanid Numnoi, Ilaria Cicalini, Damiana Pieragostino, Laura Lebrun, Carsten Janke, Stéphane Audebert, Jean‐Paul Borg, Krzysztof Rogowski, , Michael Hahne
This study identifies TTLL6 as a key polyglutamylase in the colon, showing its role in maintaining crypt integrity and preventing colon cancer progression.
bioRxiv · Dec 17, 2025 · PreprintCell Biology