This study identifies TTLL6 as a key polyglutamylase in the colon, showing its role in maintaining crypt integrity and preventing colon cancer progression.

bioRxiv · Dec 17, 2025 · PreprintCell Biology

Metabolic resilience rules sex-specific pain recovery during hormonal aging: a multi-omics analysis of neuropathy in mice.

Sara Marinelli, Cláudia Rossi, Luisa Pieroni, Giacomo Giacovazzo, Valentina Vacca, Federica De Angelis, Ilaria Cicalini, Valentina Mastrorilli, Chiara Parisi, Zuleyha Nihan Yurtsever, Domenico Ciavardelli, Roberto Coccurello

This study investigates how metabolic resilience during hormonal aging affects sex-specific recovery from nerve injury in mice using multi-omics analysis.

bioRxiv · Jun 17, 2025 · PreprintNeuroscience

Machine Learning-Based Drug Response Prediction Identifies Novel Therapeutic Candidates for Colorectal Cancer Cell Line KM-12

Cyrine Chanchabi, Conception Paul, Vincent Coulon, Ilaria Cicalini, Damiana Pierogostino, Sachin Vishwakarma, Saiveth Hernández-Hernández, Pedro J. Ballester, Michael Hahne

The paper uses machine learning to predict drug responses in colorectal cancer cells, identifying novel compounds with cytotoxic or cytostatic effects.

bioRxiv · Feb 24, 2025 · PreprintCancer Biology

Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence

Alberto Granzotto, Manuela Bomba, Vanessa Castelli, Riccardo Navarra, Noemi Massetti, Marco D’Aurora, MARCO C. ONOFRJ, Ilaria Cicalini, Piero Del Boccio, Valentina Gatta, Annamaria Cimini, Daniele Piomelli, Stefano Luca Sensi

This study shows that inhibiting de novo ceramide biosynthesis with L-cycloserine improves aging-related phenotypes in cultured cortical neurons.

Aging · Aug 29, 2019Peer-reviewedNeuroscience