D. J. Patel

Cryo-EM structure of the Spo11 core complex bound to DNA

The paper reports cryo-EM structures of Spo11 core complexes bound to DNA, revealing DNA-binding specificity and structural variation in homologs.

Kiwa is a bacterial membrane-embedded defence supercomplex activated by phage-induced membrane changes

The paper characterizes the Kiwa defence system as a bacterial membrane supercomplex that detects phage-induced membrane changes and inhibits phage replication.

Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics

This study identifies HCV NS5A inhibitors as SARS-CoV-2 exonuclease inhibitors and shows synergy in combination with polymerase inhibitors to enhance antiviral efficacy.

Vertical transmission at the pathogen-symbiont interface: Serratia symbiotica and aphids

This study shows that culturable, pathogenic Serratia symbiotica strains can be maternally transmitted via transovarial endocytosis in aphids, suggesting they have the potential to evolve into mutualistic symbionts.

A histone-like motif in yellow fever virus contributes to viral replication

This study identifies a histone-like motif in the yellow fever virus capsid protein that mimics histone H4 and interferes with BRD4-mediated gene regulation, impacting viral replication.